Dr. McGrath is a specialist in the clinical psychopharmacology of mood and anxiety disorders. He is currently Co-Director of the Depression Evaluation Service at the New York State Psychiatric Institute which conducts research into all aspects of the diagnosis and treatment of mood disorders. Special current research interests of Dr. McGrath's include pharmacogenetics, which is the effort to determine genetic determinants of response to antidepressant medications; brain imaging using positron emission tomography (PET) and functional magnetic ressonance imagaing (fMRI) to determine the biology of response to antidepressants; prediction of loss of response to antidepressant medication; and the effects of alcohol abuse and dependence on the response to antidepressants.